mercredi 11 juillet 2007

Neurogenesis in Skeletal Muscle

This week in JACS, Korean guys have published a very interesting paper concerning the induce neurogenesis of human skeletal muscle cells.
Upon Neurodazine (Nz) treatment of C2C12 cells (skeletal muscle cells) develop a neuronal phenotype, they have shown also using a mouse 20K DNA chips that Nz upregulated in particular gene which is involved in inducing neuronal differentiation.

From a chemical point a view, these guys have synthesized an imidazole library with different substituents in 1,2, 4 and 5 on solid support (Wang resin), with amino-conjuguated diethylene glycol, more than 300 imidazoles have been obtained with a purity >70%. Three different polymer supported platforms have been realized, you will see below only one example using a benzylamine derivative. The imidazole ring has been synthesized with the classical multicomponent reaction with an aldehyde (R1CHO) , an 1,2-dicarbonyl compound (R2COCOR3) , and with ammonium acetate.

R1, R2, and R3 are mainly aromatic compounds
To see the other platforms, chemistry and biological tests see Supporting info.

Synthetic Small Molecules that Induce Neurogenesis in Skeletal Muscle
Darren R. Williams, Myung-Ryul Lee, Young-Ah Song, Sung-Kyun Ko, Gun-Hee Kim, and Injae Shin
JACS, 2007, DOI:

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