vendredi 16 février 2007

Synthesis of 2,3-Dihydro-pyrrolopyridinones

Recently, Bischoff et al. has described the synthesis of 2,3-Dihydropyrrolopyridinone by a tandem aminomethylation-Cyclization using in situ generated formimine and an ortho-lithiated pyridinecarboxamide, depending on the reaction conditions it is also possible to continue the cascade reaction with a bis alkylation of the pyrrolidinone ring.

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